Nucleofill Soft Plus is a high‑viscosity polynucleotide gel formulated for sensitive skin zones. It contains 7.5 mg/ml polymerized polynucleotides at physiological pH (~6.8–7.2) for optimal tissue compatibility. This pre-filled 2 ml syringe includes 30 G needles and is ready for intradermal micro‑injections or mesotherapy. It targets fine lines, crow’s feet, puffiness, mild wrinkles, and periorbital volume loss. The polynucleotides bind water and neutralize free radicals to deeply hydrate and protect against oxidative damage. They also stimulate fibroblast activity, supporting collagen and elastin synthesis for improved dermal structure. Recommended protocol involves 3 sessions spaced 2–3 weeks apart, followed by maintenance every 3–4 months. Each session uses 0.05–0.1 ml per point via micro‑droplet technique in the superficial dermis. Results appear after the first session. Benefits include smoother texture, reduced dark circles, refreshed radiance, and restored elasticity. Outcomes can last up to 6–12 months with continued care.

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