Rejuran has emerged as one of the most sought-after skin rejuvenation treatments in aesthetic medicine. As patient demand grows, practitioners need comprehensive knowledge about this polynucleotide-based treatment to deliver optimal results and manage expectations effectively. This guide covers everything you need to know about Rejuran treatment, from mechanisms of action to clinical protocols.

What Is Rejuran Treatment?

Rejuran is an injectable skin healing treatment made from polynucleotides (PN) derived from salmon DNA. Unlike traditional dermal fillers that add volume, Rejuran works at the cellular level to repair damaged skin, stimulate collagen production, and improve overall skin quality.

The treatment is particularly popular in Asian markets and has gained significant traction in Western countries due to its regenerative properties and natural-looking results. Rejuran falls into the category of biostimulators—treatments that trigger the body’s natural healing and rejuvenation processes rather than simply filling or volumizing.

Key Components and Mechanism of Action

Rejuran contains fragmented polynucleotides (PN) extracted and purified from salmon DNA through a patented process. These polynucleotides are biocompatible with human skin and offer several therapeutic benefits:

Cellular Repair: PN fragments bind to cell surface receptors and trigger DNA repair mechanisms, helping damaged cells regenerate more effectively.

Anti-Inflammatory Effects: The treatment reduces inflammation at injection sites and throughout the treated tissue, creating an optimal environment for healing.

Collagen Stimulation: Rejuran activates fibroblasts to produce new collagen and elastin, gradually improving skin structure and firmness over time.

Improved Microcirculation: Enhanced blood flow to treated areas delivers more nutrients and oxygen to skin cells, supporting overall skin health.

Free Radical Protection: PN molecules provide antioxidant effects, protecting skin from oxidative stress and environmental damage.

Rejuran Treatment Indications

Rejuran excels at addressing multiple skin concerns, making it versatile for various patient profiles:

Primary Indications

Skin Texture Improvement: Rejuran smooths rough, uneven skin texture and minimizes pore appearance. Patients with acne-scarred skin or enlarged pores see particularly notable improvements.

Fine Lines and Wrinkles: While not a traditional wrinkle filler, Rejuran reduces fine lines by improving skin quality from within. It works exceptionally well for periorbital lines, forehead creases, and neck wrinkles.

Skin Elasticity Loss: The treatment restores firmness and bounce to aging skin, addressing early signs of sagging without surgical intervention.

Pigmentation and Uneven Tone: Rejuran helps normalize skin tone and can reduce certain types of hyperpigmentation through its regenerative effects.

Acne Scars: One of Rejuran’s most impressive applications is treating atrophic acne scars. The treatment fills depressed areas gradually through collagen stimulation.

Dehydrated Skin: Rejuran improves the skin’s moisture-retention capacity, creating lasting hydration improvements beyond what skin boosters alone can achieve.

Combination Treatment Opportunities

Rejuran works synergistically with other aesthetic treatments:

With Dermal Fillers: Use Rejuran to improve skin quality before or after volumizing treatments. The improved tissue environment can extend filler longevity.

With Botulinum Toxin: Combine with Botox for comprehensive facial rejuvenation—Botox relaxes muscles while Rejuran repairs skin quality.

With Other Polynucleotides: Layer different PN products for enhanced biostimulation effects.

Rejuran Treatment Protocol

Patient Consultation and Selection

Ideal candidates for Rejuran include patients in their late 20s to 60s seeking preventive anti-aging treatments, those with sun-damaged or environmentally stressed skin, patients with mild to moderate volume loss who want natural rejuvenation, and individuals looking to improve skin quality before events or alongside other treatments.

Contraindications include pregnancy and breastfeeding, active skin infections or inflammation in treatment areas, autoimmune conditions affecting skin, severe allergies (particularly to fish or seafood), and patients on blood thinners without medical clearance.

Treatment Technique

Preparation: Cleanse the treatment area thoroughly, apply topical anesthetic cream 20-30 minutes before injection, and mark treatment zones based on individual concerns.

Injection Method: Rejuran is typically administered using a microinjection technique—multiple small injections placed 1cm apart throughout the treatment area. The product is injected into the superficial to mid-dermis using a 30-32G needle or cannula.

Common injection patterns include:

• Full face: 2ml (1 vial) distributed evenly

• Targeted areas: 0.5-1ml per zone

• Specific scars: Precise injection directly into scar tissue

Injection Depth: Superficial dermal layer for general skin quality improvement and mid-dermal layer for deeper structural concerns. Avoid too superficial placement, which can cause temporary bumps.

Treatment Schedule

Initial Series: 3-4 treatments spaced 2-4 weeks apart provide optimal results for most patients.

Maintenance: After completing the initial series, maintenance treatments every 6-12 months sustain improvements.

Aggressive Protocols: For severe skin damage or scarring, monthly treatments for 6 months may be necessary.

Rejuran Before and After: Setting Patient Expectations

Managing expectations is crucial for patient satisfaction with Rejuran treatment.

Timeline of Results

Immediate (Days 1-3): Mild swelling and redness, small bumps at injection sites (normal and temporary), slight skin glow from hydration.

Early Phase (Weeks 1-4): Reduction in redness and inflammation, improved skin texture becomes noticeable, enhanced radiance and hydration.

Progressive Improvement (Months 1-3): Gradual reduction in fine lines, improved skin elasticity and firmness, continued collagen remodeling, optimal results typically visible at 3 months post-treatment.

Long-term (Months 3-12): Sustained improvements in skin quality, continued collagen production, maintained texture and tone improvements.

Realistic Outcome Expectations

Rejuran provides subtle, natural-looking improvements rather than dramatic transformations. It excels at creating healthier, more resilient skin with improved texture and tone. Patients should understand that results are cumulative—each treatment builds upon previous sessions.

For best results, combine Rejuran with proper skincare, sun protection, and healthy lifestyle habits.

Side Effects and Management

Rejuran is generally well-tolerated, but practitioners should prepare patients for common temporary effects:

Expected Post-Treatment Effects

Injection Site Reactions: Small bumps or wheals at injection points (resolve within 24-48 hours), mild swelling (peaks at 24 hours, subsides within 2-3 days), temporary redness (typically resolves within hours).

Management: Apply cold compresses immediately post-treatment, advise patients to sleep elevated the first night, and avoid strenuous exercise for 24 hours.

Rare Complications

While uncommon, practitioners should monitor for bruising (more common in vascular areas), prolonged swelling (lasting beyond 5 days), infection (extremely rare with proper sterile technique), and allergic reactions (very rare but possible).

Differentiating Rejuran from Other Treatments

Understanding how Rejuran differs from other popular treatments helps practitioners make appropriate recommendations:

Rejuran vs. Dermal Fillers

Rejuran: Repairs and regenerates tissue, provides gradual improvement, enhances skin quality, and results build over time.

Dermal Fillers: Add volume and structure, create immediate visible changes, and fill lines or enhance features directly.

Rejuran vs. Skin Boosters

Rejuran: Contains polynucleotides for cellular repair, stimulates collagen production, and provides longer-lasting structural improvements.

Skin Boosters: Primarily hyaluronic acid for hydration, improve skin moisture and glow, and typically require more frequent maintenance.

Rejuran vs. Other Polynucleotides

Different polynucleotide products have varying molecular weights and concentrations. Rejuran specifically uses salmon-derived PN with proven clinical efficacy, while other PN products may have different molecular structures or origins.

Clinical Tips for Success

Start Conservative: Begin with standard protocols before increasing frequency or dosage. Over-treatment provides minimal additional benefit.

Combine Strategically: Use Rejuran as a foundation treatment to improve tissue quality before adding volumizing fillers or neurotoxins for comprehensive rejuvenation.

Document Thoroughly: Take standardized photos before each treatment session. Progressive improvements are subtle and photographic evidence helps patients appreciate results.

Educate Patients: Provide written aftercare instructions, set realistic timelines for results, and explain the cumulative nature of the treatment.

Address Concerns Promptly: If patients experience prolonged side effects, assess and treat appropriately. Most reactions resolve with conservative management.

Rejuran in Your Treatment Portfolio

Rejuran treatment offers practitioners an effective tool for skin quality improvement and patient satisfaction. Its regenerative approach appeals to patients seeking natural rejuvenation without dramatic changes.

By understanding the science behind Rejuran, mastering injection techniques, and setting appropriate expectations, practitioners can successfully integrate this treatment into their practice. Whether used alone or as part of comprehensive treatment plans, Rejuran provides valuable solutions for modern aesthetic concerns.

For practitioners looking to expand their injectable offerings beyond traditional volumizing treatments, Rejuran represents an excellent addition that addresses the growing demand for regenerative aesthetic medicine. Success with Rejuran requires patience, precision, and thorough patient education—but the results speak for themselves in healthier, more radiant skin.

Looking to build your aesthetic practice? Check out our guide on 5 rules for building a successful injectable practice for more insights.